Contraceptive effectiveness and safety of ormeloxifene: a systematic review.
BMJ Sex Reprod HealthSep 23, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Tesfaye Tufa, Muhammad Idrees, Goodness Ogeyi Odey et al.
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In 30 seconds
This systematic review evaluated the contraceptive effectiveness and safety of ormeloxifene among reproductive-age women, analyzing 14 studies. The Pearl Indices ranged from 0.48 to 4.2 per 100 woman-years, indicating moderate effectiveness. No serious adverse events were reported, suggesting a favorable safety profile.
Key findings
- Pearl Indices for ormeloxifene ranged from 0.48 to 4.2 per 100 woman-years.
- Failure rates varied between 0.8% and 10.1% across studies.
- No serious adverse events like thromboembolism or hepatotoxicity were reported.
- Method satisfaction was high, ranging from 75% to 95%.
Why it matters
Understanding the effectiveness and safety of new contraceptive options like ormeloxifene is crucial for clinicians to provide informed choices to patients, especially in regions with limited access to hormonal contraceptives.
What to keep in mind
All studies on contraceptive use were conducted in India and had a high risk of bias.