Efficacy and safety of Braun enteroenterostomy in patients undergoing pancreatoduodenectomy: a systematic review and meta-analysis.
Marios Alogakos, Ahmed Ghani, Stefan Bitar et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy and safety of Braun enteroenterostomy (BEE) in 2731 patients undergoing pancreatoduodenectomy (PD). The study found that BEE significantly reduced the rates of delayed gastric emptying (DGE) and postoperative pancreatic fistula (POPF), with odds ratios of 0.39 and 0.68, respectively. However, these findings were not confirmed in a subgroup analysis of randomized controlled trials.
Key findings
- BEE reduced the rate of overall DGE (OR = 0.39, 95% CI 0.28, 0.54).
- Patients with BEE had a lower rate of clinically relevant DGE (OR = 0.36, 95% CI 0.23, 0.57).
- The rate of reoperation was lower in patients with BEE (OR = 0.35, 95% CI 0.20, 0.64).
- Operative time was longer in patients with BEE (MD = 12.6 min; 95% CI 0.9, 24.3).
Why it matters
Understanding the impact of BEE on complications after PD is crucial for improving patient outcomes. The reduction in DGE and POPF rates suggests that BEE may enhance recovery, although further research is needed to confirm these benefits.
What to keep in mind
Findings from subgroup analysis of randomized controlled trials did not support the overall results, indicating potential limitations in the evidence.