Western versus Asian utilization of molecular testing for indeterminate thyroid nodules: A meta-analysis of divergent clinical impact.
Cancer CytopatholSep 25, 2026
Chanchal Rana, Truong Phan-Xuan Nguyen, Chan Kwon Jung et al.
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In 30 seconds
This meta-analysis examined the use of molecular testing (MT) for indeterminate thyroid nodules in Western and Asian populations. It included 127 studies and found that MT significantly reduced surgical interventions in both regions, with a higher risk of malignancy in Asian cohorts (62.7% vs 37.1% with MT, p < .001).
Key findings
- Without MT, resection rates were 66.8% in Western studies versus 53.9% in Asian studies (p = .11).
- With MT, resection rates were 42.5% in Western studies compared to 37.4% in Asian studies (p = .275).
- Risk of malignancy was significantly higher in Asian cohorts with MT at 62.7% versus 37.1% in Western cohorts (p < .001).
- Second-generation platforms in Western studies had lower resection rates (36.1% vs 48.3%; p = .001) but higher ROM (42.8% vs 34.4%; p = .005).
Why it matters
Understanding regional differences in the application of molecular testing for thyroid nodules can inform clinical decision-making and improve patient management strategies. Tailored guidelines may enhance the effectiveness of interventions based on local malignancy rates.