The Psychosocial Impact of Receiving Whole Genome and Whole Exome Sequencing Results in Adults: A Systematic Review.
J Genet CounsSep 25, 2026
Clinical ResearchMedical Genetics
Monica Albu, Andrada Ciucă, Ramona Moldovan
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In 30 seconds
This systematic review assessed the psychosocial impact of whole genome sequencing (WGS) and whole exome sequencing (WES) results in adults, analyzing 45 studies. The review found that while positive experiences were common, negative experiences were typically of low intensity. Overall, benefits generally outweighed risks of psychological distress.
Key findings
- Positive experiences were reported by participants, highlighting satisfaction from increased health insight.
- Negative experiences were frequently reported but usually of low intensity.
- Individuals receiving genetic counseling experienced less uncertainty regarding their results.
- Sharing of test results was common, with participants understanding implications for themselves and others.
Why it matters
Understanding the psychosocial impact of WGS and WES is crucial for clinicians to provide appropriate support and counseling to patients, ensuring they are prepared for the potential emotional and social implications of their genetic information.