Prognostic Value of the C-Reactive Protein-Albumin-Lymphocyte Index in Hepatobiliary and Pancreatic Cancers: A Systematic Review and Meta-Analysis.
Mohammadsadra Shamohammadi, Ehsan Arianezhad, Danial Yarahmadi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index in patients with hepatobiliary and pancreatic cancers. The analysis included 16 studies with 3,833 participants, revealing that a high CALLY index is associated with improved overall survival (HR 0.50) and recurrence-free/disease-free survival (HR 0.60).
Key findings
- High CALLY was associated with better overall survival (HR 0.50, 95% CI 0.44-0.58).
- High CALLY correlated with improved recurrence-free/disease-free survival (HR 0.60, 95% CI 0.49-0.73).
- Cancer-specific overall survival favored high CALLY in hepatocellular carcinoma (HR 0.58).
- Heterogeneity in CCA outcomes was reduced significantly with anatomical stratification.
Why it matters
Understanding the prognostic implications of the CALLY index could help clinicians better assess survival outcomes in patients with hepatobiliary and pancreatic cancers, potentially guiding treatment decisions.
What to keep in mind
Predominantly retrospective evidence, heterogeneous clinical settings, and variable cutoffs limit the routine clinical application of the CALLY index.