Adjunctive Use of Botulinum Toxin in Orthognathic Surgery: A Systematic Review of Current Evidence and Clinical Perspectives.
Audra Janovskienė, Justina Stučinskaitė-Maračinskienė, Žygimantas Petronis et al.
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In 30 seconds
This systematic review evaluated the adjunctive use of botulinum toxin type A (BoNT-A) in orthognathic surgery, analyzing three studies, including two randomized controlled trials. The review found associations between BoNT-A and reduced fixation plate fractures and lower postoperative pain scores, but results varied significantly across studies. The evidence is insufficient for definitive conclusions.
Key findings
- BoNT-A administration was associated with a lower incidence of fixation plate fracture.
- Reduced anteroposterior skeletal relapse at the Pogonion was noted in some studies.
- Lower preanalgesic pain scores and postoperative opioid consumption were reported.
Why it matters
Understanding the potential benefits of BoNT-A in orthognathic surgery could enhance postoperative recovery and stability, addressing common complications such as fixation failure and pain management.
What to keep in mind
The review is limited by the small number of studies and significant clinical heterogeneity in interventions and outcomes.