Classic mantle cell lymphoma with aberrant immunohistochemical expression of Fc receptor-like 4/immunoglobulin superfamily receptor translocation-associated 1.
Allison Kaye Lombridas Pagarigan, Danai Samutpradit, Weerapat Owattanapanich et al.
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Case in brief
A patient diagnosed with classic mantle cell lymphoma (MCL) presented with typical clinical, morphologic, immunophenotypic, and genetic features. However, this case was notable for the aberrant co-expression of the Fc receptor-like 4 (FcRL4) and immunoglobulin superfamily receptor translocation-associated 1 (IRTA1) markers, which are usually negative in MCL. The implications of this finding on prognosis are explored.
What made this case unusual
The case is distinguished by the unexpected co-expression of FcRL4/IRTA1 in a patient with classic mantle cell lymphoma, a finding not typically associated with this diagnosis.
Diagnostic / clinical pearl
Clinicians should be aware that aberrant expression of FcRL4/IRTA1 may occur in mantle cell lymphoma, potentially influencing prognostic assessments.
Why it matters
Understanding the implications of aberrant immunohistochemical markers in lymphoma can aid in refining diagnostic and prognostic evaluations.