Long-term natural history of spontaneous closure of a full-thickness macular hole in retinitis pigmentosa.

BMJ Case RepSep 24, 2026 (epub)
Case ReportOphthalmology

Claire W Ruan, Matthew George Schneiders, Muhammad Raja

✦ AI-curated · Sources linked

Case in brief

A middle-aged woman with retinitis pigmentosa presented with a non-tractional full-thickness macular hole. After 18 years of follow-up, the macular hole closed spontaneously, resulting in a stable lamellar configuration without recurrence. Visual acuity declined over time, attributed to retinal degeneration and cataract progression, while optical coherence tomography confirmed long-term foveal stability.

Diagnostic / clinical pearl

This case highlights that spontaneous closure of a non-tractional full-thickness macular hole in retinitis pigmentosa can occur and remain stable over an extended period, suggesting that careful observation may be appropriate in select cases.

Source

PubMed · PMID 42785779

Published in BMJ Case Rep. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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