Acrokeratosis paraneoplastica (Bazex syndrome): a systematic review and quantitative analysis of 106 cases.
Mustafa Sefa Isin, Mehmet Berke Isler, Amor Khachemoune
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From the abstract
Acrokeratosis paraneoplastica (Bazex syndrome) is an obligate paraneoplastic dermatosis characterized by symmetrical acral psoriasiform lesions and nail dystrophy.
Reported results
The mean age at onset was 63.5 years (median: 62.5 years; interquartile range [IQR]: 57-70 years); men comprised 72.6% (n = 77; 95% CI, 63.5%-80.2%), yielding a male-to-female ratio of 2.7:1. Squamous cell carcinoma accounted for 51.9% (55/106; 95% CI, 42.5%-61.2%) of associated malignancies, followed by adenocarcinomas (18.9%; 95% CI, 12.6%-27.4%) and hematologic neoplasms (8.5%; 95% CI, 4.5%-15.4%).
Authors' conclusions
Bazex syndrome should be suspected in patients presenting with treatment-resistant acral psoriasiform lesions and nail dystrophy, prompting rigorous malignancy screening.