Fospropofol vs Propofol for Early Postoperative Nausea and Vomiting Prophylaxis in High-Risk Patients Undergoing Gynecological Laparoscopic Surgery: A Randomized Controlled Trial.
Li Ma, Yundong Guo, Wenjie Wang et al.
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From the abstract
Postoperative nausea and vomiting (PONV) is a common complication of gynecological laparoscopic surgeries. Although propofol has established antiemetic properties, the efficacy of its water-soluble prodrug, fospropofol, for PONV prophylaxis remains uncertain.
Reported results
The incidence of PONV at 6 h was significantly lower in the FD group than in the P group (5.9% vs 19.6%; absolute risk reduction, 13.7%; P =0.038). Multivariable logistic regression confirmed that fospropofol was an independent protective factor (odds ratio 0.219; 95% CI 0.045-0.809; P =0.034). No significant between-group differences were observed in the PACU- or 24-h PONV rates.
Authors' conclusions
A reduction in early PONV within 6 hours was observed with fospropofol compared to propofol, suggesting a potential role for fospropofol in early PONV prevention.