Phlegmonous Gastritis Refractory to Antibiotics with Subsequent Improvement on Empiric Quadruple Therapy.
Aditya Sharma, Sangini Tolia, Sarvani Surapaneni et al.
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Case in brief
A 59-year-old woman presented with two days of severe nausea, vomiting, and inability to tolerate oral intake while on chronic proton-pump inhibitor therapy. She exhibited leukocytosis and imaging revealed diffuse gastric wall thickening. Endoscopy showed severe gastric mucosal abnormalities, and biopsy confirmed acute purulent gastritis without Helicobacter pylori. After an inadequate response to broad-spectrum antibiotics, she improved with empiric quadruple therapy.
Diagnostic / clinical pearl
Phlegmonous gastritis can present with nonspecific symptoms and may not respond to standard antibiotic therapy, necessitating consideration of empiric quadruple therapy.