Effectiveness of Lactobacillus-supplemented eradication therapy for Helicobacter pylori: a systematic review and meta-analysis of randomized controlled trials.
Eur J Clin PharmacolSep 26, 2026 (epub)
Karollyna M Henry Moore, Paula Santo, Erica Uchoa Holanda et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of Lactobacillus-supplemented Helicobacter pylori eradication therapy across 32 randomized controlled trials involving 4,010 patients. The study found that Lactobacillus supplementation improved eradication success by 10% (RR 1.10; 95% CI 1.05-1.14) and reduced adverse events by 30% (RR 0.70; 95% CI 0.58-0.84).
Key findings
- Lactobacillus supplementation improved eradication success by 10% (RR 1.10; 95% CI 1.05-1.14).
- The number needed to treat for eradication success was 13.
- Adverse events were reduced by 30% (RR 0.70; 95% CI 0.58-0.84).
- Improved eradication success was noted only with triple therapy regimens.
Why it matters
The findings suggest that incorporating Lactobacillus into Helicobacter pylori eradication therapy may enhance treatment efficacy and minimize adverse effects, which is crucial for improving patient compliance and outcomes.