Acquired paroxysmal dysarthria-ataxia syndrome: A systematic review of clinical and MRI findings.
Neurol SciSep 26, 2026 (epub)
Krzysztof Smolik, Pedro Fraiman, João Claudio Urbano et al.
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In 30 seconds
This systematic review examined acquired paroxysmal dysarthria-ataxia syndrome (PDAS) in 31 patients across 25 studies, revealing that PDAS is not limited to Multiple Sclerosis. The mean age of onset was 52 years, with favorable outcomes observed in 93% of patients after treatment, primarily with antiepileptic drugs.
Key findings
- 71% of patients with PDAS were male, with a mean age of onset of 52 years.
- The most common diagnosis was Multiple Sclerosis, found in 39% of patients.
- Lesions were predominantly located in the midbrain, seen in 65% of patients.
- 93% of patients experienced complete resolution of symptoms after pharmacological treatment.
Why it matters
Understanding the diverse aetiologies and favorable treatment outcomes of PDAS can aid clinicians in recognizing and managing this syndrome effectively, potentially improving patient care and prognosis.