Network meta-analysis of intrathyroidal injection of combined dexamethasone with lidocaine for subacute thyroiditis.
Hongxia Wei, Yong Huang, Binyi Li
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In 30 seconds
This meta-analysis evaluated the efficacy of intrathyroidal dexamethasone (Dex) versus oral prednisone and compared combination therapy of Dex with lidocaine to monotherapy in treating subacute thyroiditis (SAT). The analysis included 23 studies and found that intrathyroidal Dex significantly improved clinical efficacy and reduced symptom remission time compared to oral prednisone. Monotherapy was suggested as the optimal approach.
Key findings
- Intrathyroidal injection of Dex significantly increased clinical efficacy compared to oral prednisone.
- Monotherapy showed a recurrence rate of 79.9% and remission time of fever at 83.6%.
- Combination therapy did not provide additional benefits over monotherapy for SAT treatment.
Why it matters
Understanding the most effective treatment options for subacute thyroiditis is crucial for optimizing patient outcomes. This study highlights the superiority of intrathyroidal dexamethasone over oral prednisone and suggests that monotherapy may be preferable.