Pancreatic arteriovenous malformations as a manifestation of hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease): a systematic review.
BMJ Open GastroenterolSep 25, 2026 (epub)
Isabel de Jager, Ebba Asplund, Nikolaos Kartalis et al.
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In 30 seconds
This systematic review examined pancreatic arteriovenous malformations (AVMs) in patients with hereditary hemorrhagic telangiectasia (HHT), analyzing 19 cases from 13 studies. The findings revealed that 50% of patients were asymptomatic, with a mean AVM size of 7.1 mm. Most patients received conservative treatment, highlighting the unique presentation of AVMs in this population.
Key findings
- 50% of patients presented asymptomatically without laboratory findings.
- The mean AVM size was 7.1 mm.
- 69% of patients were treated conservatively.
- 75% of differential diagnoses were neuroendocrine tumors.
Why it matters
Understanding the characteristics and management of pancreatic AVMs in HHT patients is crucial for clinicians, as these cases may differ significantly from typical presentations, influencing diagnostic and treatment approaches.