Low-intensity pulsed ultrasound to facilitate uterine involution: prospective multicenter study on clinical efficacy and mechanistic insights.
Ultrasound Obstet GynecolSep 27, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
H-L Liu, L-M Xie, J Wang et al.
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In 30 seconds
This multicenter, randomized controlled trial evaluated the efficacy of low-intensity pulsed ultrasound (LIPUS) in promoting uterine involution post-delivery among 1,106 women. Results indicated that LIPUS significantly reduced uterine volume and fundal height descent index, with a lower incidence of secondary postpartum hemorrhage and puerperal infection (all P < 0.05).
Key findings
- LIPUS-treated participants showed a greater percentage reduction in uterine volume compared to controls.
- The incidence of secondary postpartum hemorrhage was lower in the LIPUS group.
- LIPUS was associated with increased contractility of uterine tissue strips and elevated intracellular Ca 2+ levels.
- Expression levels of endothelin-1 and oxytocin receptor were significantly higher in LIPUS-treated tissues.
Why it matters
The findings suggest that LIPUS may serve as a non-invasive method to enhance uterine involution and reduce postpartum complications, potentially improving maternal health outcomes.