Determinants of preterm pre-eclampsia following low-dose aspirin prophylaxis: evidence from stepped-wedge cluster randomized trial in Asia.
Ultrasound Obstet GynecolSep 27, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
J Lin, L Nguyen-Hoang, L T Dinh et al.
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In 30 seconds
This multicenter stepped-wedge cluster randomized trial studied 2919 high-risk pregnant women receiving low-dose aspirin prophylaxis to identify risk factors for preterm pre-eclampsia (PE). The study found that chronic hypertension, mean arterial pressure (MAP) multiples of the median > 1.149, and higher estimated risk were significantly associated with preterm PE, with an incidence of 3.7%.
Key findings
- Chronic hypertension was associated with aOR of 1.835 for preterm PE.
- MAP MoM > 1.149 increased odds of preterm PE with aOR of 2.162.
- Women with estimated risks of 1:2 to 1:5 had a 16-fold higher odds of developing preterm PE.
- Chronic hypertension increased the risk of delivering with PE by aHR of 2.979.
Why it matters
Understanding the determinants of preterm PE in high-risk populations can enhance risk stratification and inform preventive strategies, potentially improving maternal and fetal outcomes.