Effective Dose 90 of Programmed Intermittent Epidural Bolus Volume at Three Ropivacaine Concentrations with Dural Puncture Epidural for Labor Analgesia: A Randomized Sequential Allocation Study.
Drug Des Devel TherSep 23, 2026 (epub)
Linsen Sun, Xiaojuan Ding, Peng Zhai et al.
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In 30 seconds
This randomized controlled trial evaluated the effective dose 90 (ED90) of programmed intermittent epidural bolus (PIEB) volume for labor analgesia using three concentrations of ropivacaine (0.075%, 0.1%, 0.125%) in 90 patients. The study found that the ED90 of PIEB volume decreased with increasing ropivacaine concentration, with values of 13.2 mL, 11.1 mL, and 9.4 mL respectively.
Key findings
- ED90 of PIEB volume was 13.2 mL for 0.075% ropivacaine.
- ED90 of PIEB volume was 11.1 mL for 0.1% ropivacaine.
- ED90 of PIEB volume was 9.4 mL for 0.125% ropivacaine.
- No significant differences in maternal analgesia quality or neonatal outcomes among groups.
Why it matters
Understanding the ED90 of PIEB volume at varying ropivacaine concentrations can help clinicians optimize labor analgesia, ensuring effective pain management while minimizing medication use.