Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.
Colorectal DisSep 29, 2026
Clinical ResearchGastroenterology
Mohammadreza Heidari, Amir Mohammad Azizpour, Maryam Rayatpisheh et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the long-term outcomes of stem cell-based interventions for Crohn's disease-related perianal fistulas in 750 patients. The primary analysis of randomized controlled trials revealed a pooled long-term healing rate of 59% (95% CI, 51%-67%). Overall, stem cell therapy appears to be a safe and effective option for this challenging condition.
Key findings
- The pooled long-term healing rate in RCTs was 59% (95% CI, 51%-67%).
- An exploratory analysis across all studies showed an overall healing rate of 63% (95% CI 55%-70%).
- No treatment-related deaths or definitively therapy-associated malignancies were reported.
- Safety profiles were favorable across all included studies.
Why it matters
Understanding the long-term efficacy and safety of stem cell-based therapies for perianal fistulas in Crohn's disease is crucial for clinicians managing patients with this complex condition, particularly when conventional treatments fail.