Changes in renal function in patients with chronic kidney disease after ureteroscopy: a systematic review and meta-analysis from EAU endourology.
Ali Talyshinskii, María Florencia Frascheri, Lazaros Tzelves et al.
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In 30 seconds
This systematic review and meta-analysis evaluated changes in estimated glomerular filtration rate (eGFR) after ureteroscopy (URS) or retrograde intrarenal surgery (RIRS) in patients with chronic kidney disease (CKD). Analyzing data from seven studies with 742 patients, the pooled mean difference in eGFR was +2.8 mL/min/1.73 m², indicating no significant overall change in renal function.
Key findings
- Pooled mean difference in eGFR was +2.8 mL/min/1.73 m², p = 0.27, indicating no significant change.
- In the ureteral stone subgroup, eGFR increased by +12.26 mL/min/1.73 m², but this was based on a single study.
- No studies reported progression to dialysis due to ureteroscopic intervention.
- Evidence certainty was rated very low, necessitating further prospective studies.
Why it matters
Understanding the impact of URS and RIRS on renal function in CKD patients is crucial for clinicians to make informed decisions regarding intervention risks and benefits, particularly in managing obstructive uropathy.
What to keep in mind
Evidence certainty remains very low, highlighting the need for prospective studies with standardized long-term assessment.