Primary adrenal lymphoma presenting as primary adrenal insufficiency.
Khaled Ahmed, Efstratios Stratos, Louis Saada et al.
✦ AI-curated · Sources linked
Case in brief
A man in his late 60s presented with symptoms of adrenal failure, including anaemia and hypercalcaemia. Initial tests indicated adrenal insufficiency, and imaging showed bilateral adrenal enlargement. An adrenal biopsy confirmed diffuse large B-cell lymphoma. The patient responded well to first-line immunochemotherapy, achieving complete metabolic remission, although his adrenal function did not fully recover.
Diagnostic / clinical pearl
Clinicians should consider primary adrenal lymphoma in patients presenting with adrenal insufficiency, especially when standard autoimmune or congenital causes are excluded.
Why it matters
This case highlights the importance of thorough diagnostic evaluation in patients with unexplained adrenal insufficiency, as it may reveal rare underlying conditions like primary adrenal lymphoma.