Efficacy of a needle-free blood collection device (PIVO Pro) for avoiding contaminated blood culture sets in Australian emergency departments: protocol for an adaptive group sequential randomised controlled trial.
Josephine Lovegrove, Andrea Valks, Daner Ball et al.
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In 30 seconds
This study protocol outlines a multicentre, adaptive group sequential randomised controlled trial aimed at evaluating the efficacy of the needle-free blood collection device, PIVO Pro, in reducing blood culture contamination compared to standard venepuncture practices in Australian emergency departments. The trial will include approximately 1148 adults requiring blood cultures and aims to assess contamination rates as the primary outcome.
Key findings
- The primary outcome is contamination rates in blood cultures, assessed as yes/no.
- Secondary outcomes include bottle underfill and culture quality.
- Patients receiving intravenous antimicrobials prior to sample collection will be excluded.
Why it matters
Blood culture contamination can significantly affect the diagnosis and treatment of bloodstream infections. This trial could provide critical evidence on whether a needle-free device can improve the accuracy of blood cultures, potentially leading to better patient outcomes.