Prevalence of Cerebellar Cognitive Affective Syndrome in Patients with Cerebellar Disorders: A Systematic Review and Meta-Analysis.
Tokuaki Shinya, Shota Tanaka, Kota Yamauchi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the prevalence of cerebellar cognitive affective syndrome (CCAS) in patients with cerebellar disorders. Analyzing 15 studies with 712 participants, the pooled prevalence of definite CCAS was found to be 67% (95% CI, 53%-79%). The study highlights significant variability in assessment methods and risk of bias among included studies.
Key findings
- Pooled prevalence of definite CCAS was 67% (95% CI, 53%-79%) among CCAS-Scale studies.
- Two conventional neuropsychological studies reported CCAS prevalence of 22.2% and 55.6%.
- Proportions of CCAS categories were 7% for no CCAS, 18% for possible, 15% for probable, and 62% for definite CCAS.
- Sensitivity analyses yielded prevalence estimates of 65%-69%.
Why it matters
Understanding the prevalence of CCAS is crucial for clinicians managing patients with cerebellar disorders, as it can inform diagnosis and treatment strategies. The high prevalence indicates a need for awareness and potential screening in this population.
What to keep in mind
Five of the included studies were at high risk of bias, and considerable heterogeneity limits the applicability of pooled estimates.