Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post-Mastectomy: A Case Report.
Taro Miyake, Hidenori Sasa, Tsubasa Ito et al.
✦ AI-curated · Sources linked
Case in brief
A 69-year-old woman, 30 years post-mastectomy for invasive ductal carcinoma, presented with abnormal cervical cytology. Imaging revealed a 38-mm cervical mass, leading to a modified radical hysterectomy. Histological analysis confirmed metastatic invasive ductal carcinoma, with a notable receptor conversion to HER2-positive status, despite the primary tumor being hormone receptor-positive.
What made this case unusual
This case is notable for the cervical metastasis occurring 30 years after the initial breast cancer surgery, highlighting a rare long-term metastatic presentation.
Diagnostic / clinical pearl
Clinicians should consider metastatic breast cancer in the differential diagnosis of cervical masses in breast cancer survivors, regardless of the time elapsed since the primary diagnosis.
Why it matters
This case emphasizes the need for receptor re-evaluation in metastatic lesions, which is crucial for guiding targeted therapy.