Bipolar Disorder and Perimenopause: An Update.

In 30 seconds

This systematic review examined the relationship between bipolar disorder (BD) and perimenopause, analyzing 14 studies from various countries. It found that perimenopause is associated with a higher risk of first onset BD and increased depressive symptoms in individuals with existing BD. The review highlights the need for further research on treatment options during this period.

Key findings

• Perimenopause is linked to a higher risk of first onset bipolar disorder.
• Increased depression and heightened anxiety were consistently observed in individuals with existing bipolar disorder during perimenopause.
• Findings regarding hypo/mania during perimenopause were mixed.
• Evidence on treatment options, including hormone replacement therapy, was limited.

Why it matters

Understanding the interplay between perimenopause and bipolar disorder is crucial for clinicians, as it may influence treatment strategies and patient management during this transitional phase of life.