The role of vitamin D signalling in β cell apoptosis: a systematic review.

In 30 seconds

This systematic review examined the role of vitamin D signalling in pancreatic β-cell apoptosis, analyzing 26 studies across various models. The findings suggest that vitamin D generally protects β-cells from apoptosis induced by multiple stressors, although effects can vary based on the model and context. Notably, VDR activation was linked to improved β-cell survival and function.

Key findings

• Vitamin D signalling protects β-cells from apoptosis due to cytokine-mediated inflammation and oxidative stress.
• VDR activation improved mitochondrial stability and modulated Bcl-2 family proteins.
• Calcitriol was associated with growth inhibition and increased apoptosis in βTC insulinoma models.
• Effects of vitamin D on β-cell survival are model- and context-dependent.

Why it matters

Understanding the protective role of vitamin D in β-cell apoptosis could inform therapeutic strategies for diabetes management, particularly in mitigating cellular stress and preserving β-cell function.