Gastric neuroendocrine tumours after prolonged proton pump inhibitor use.
Janet Song, Jeffrey Bien, Elena Hristova et al.
✦ AI-curated · Sources linked
Case in brief
A woman in her 40s with chronic gastro-oesophageal reflux disease had been on proton pump inhibitors for 20 years. She was diagnosed with gastric neuroendocrine tumours during an upper endoscopy. Extensive evaluations excluded known causes of gNETs. Following the discontinuation of PPIs and endoscopic resection of the tumours, her biomarkers normalized.
What made this case unusual
The case presents a rare occurrence of sporadic gastric neuroendocrine tumours following prolonged proton pump inhibitor use, which is not commonly reported.
Diagnostic / clinical pearl
Clinicians should be aware of the potential association between long-term proton pump inhibitor use and the development of gastric neuroendocrine tumours.
Why it matters
This case emphasizes the need for careful consideration of prolonged PPI therapy in patients with chronic GERD symptoms to prevent rare but significant complications.