Pembrolizumab plus Chemotherapy for Synchronous Multiple Primary Esophageal and Gingival Squamous Cell Carcinomas.

Anticancer ResOct 1, 2026
Case ReportOncology (Medical)

Hotaka Tamura, Yukiko Otsuki, Ayumu Hosokawa

✦ AI-curated · Sources linked

Case in brief

A 68-year-old man presented with synchronous squamous cell carcinomas of the esophagus and mandibular gingiva. He received pembrolizumab combined with cisplatin and 5-fluorouracil, leading to a clinical complete response in the gingival and metastatic lesions, and a near-complete response in the esophageal tumor. The treatment was well-tolerated, allowing the patient to regain oral intake and body weight.

Diagnostic / clinical pearl

This case highlights the potential efficacy of PD-1 blockade in patients with multiple primary cancers, despite limited evidence in this population.

Source

PubMed · PMID 42823147

Published in Anticancer Res. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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