Surgical Resection of Metachronous Liver Metastases in Non-colorectal Non-neuroendocrine Gastrointestinal Cancers: Systematic Review and Meta-analysis.
Arianna Cicolani, Lucio Chiarini, Marta Goglia et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of surgical resection on overall survival in patients with metachronous liver metastases from non-colorectal non-neuroendocrine gastrointestinal cancers. The analysis included ten comparative studies, revealing that surgical treatment was associated with significantly higher overall survival at 1 year (RR=1.93, 95% CI=1.26-2.98) compared to non-surgical management.
Key findings
- Surgical treatment was associated with significantly higher overall survival at 1 year (RR=1.93, 95% CI=1.26-2.98).
- A favorable trend for surgical treatment was observed at 3 years (RR=2.45, 95% CI=0.99-6.11).
- At 5 years, surgical treatment showed a trend favoring surgery (RR=2.26, 95% CI=0.97-5.29).
- Substantial heterogeneity was noted across studies (I 2 =67-86%).
Why it matters
The findings suggest that surgical resection may improve survival outcomes for patients with metachronous liver metastases from non-colorectal non-neuroendocrine gastrointestinal cancers, an area with previously limited evidence. This could influence treatment decisions in clinical practice.