Alpha-catenin Mutation-associated Synchronous Follicular Thyroid Carcinoma and Papillary Thyroid Carcinoma With Numerous Adenomatoid Nodules.
Ran Wang, Q I Zhang, Ruohao Fan et al.
✦ AI-curated · Sources linked
Case in brief
A 59-year-old woman with a history of breast cancer was found to have a thyroid nodule during a chest CT. Subsequent biopsies revealed synchronous minimally invasive follicular thyroid carcinoma and classic papillary thyroid carcinoma, alongside numerous adenomatoid nodules. Genetic testing confirmed a pathogenic CTNNA1 mutation, suggesting a link between this mutation and the observed thyroid lesions.
What made this case unusual
The presence of synchronous follicular and papillary thyroid carcinomas in conjunction with numerous adenomatoid nodules is an atypical finding associated with a CTNNA1 mutation.
Diagnostic / clinical pearl
Clinicians should consider the potential for multiple thyroid proliferative lesions in patients with a CTNNA1 mutation, as this may indicate a hereditary cancer predisposition.
Why it matters
This case highlights the need for awareness of the relationship between CTNNA1 mutations and diverse thyroid neoplasms, which may be underrecognized in clinical practice.