Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta-Analysis of Randomized Controlled Trials Using the REB Method.
Fundam Clin PharmacolOct 3, 2026
Natalia Kostakis, Jean-Christophe Lega, Remy Boussageon
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In 30 seconds
This meta-analysis reviewed 25 randomized controlled trials (RCTs) to evaluate the impact of vitamin D supplementation on mortality in individuals aged 75 and older. The analysis focused on 8 RCTs with low risk of bias, involving 30,320 participants, and found a statistically significant reduction in all-cause mortality with a relative risk of 0.96 (95% CI [0.92, 1.00], p = 0.04).
Key findings
- The analysis included 8 RCTs with low risk of bias and 30,320 participants.
- Vitamin D supplementation showed a statistically significant reduction in mortality with RR = 0.96.
- Seven RCTs raised concerns about bias, while two were at high risk of bias.
Why it matters
Understanding the potential benefits of vitamin D supplementation in the elderly is crucial for clinicians, as it may influence strategies for reducing mortality in this vulnerable population.