Therapeutic value of continuous subcutaneous insulin infusion with electrolyte supplementation for pediatric diabetic ketoacidosis.
Wei Li, Hongxia Zhang, Qing Li et al.
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In 30 seconds
This randomized controlled trial evaluated the efficacy and safety of continuous subcutaneous insulin infusion (CSII) with electrolyte supplementation in 66 pediatric patients with diabetic ketoacidosis (DKA). The CSII group demonstrated significantly improved outcomes, including faster pH normalization and better blood glucose control, compared to the intravenous insulin group, with all results showing P < 0.05.
Key findings
- CSII group achieved faster pH normalization and target blood glucose levels compared to the control group.
- Lower levels of BUN, creatinine, and inflammatory markers were observed in the CSII group.
- The CSII group had a lower rate of adverse reactions than the intravenous insulin group.
Why it matters
The findings suggest that CSII with electrolyte supplementation may enhance treatment outcomes in pediatric DKA, potentially leading to safer management of this critical condition. Improved regulation of blood glucose and electrolytes can reduce complications associated with traditional intravenous therapy.