Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.
Medicine (Baltimore)Oct 2, 2026
Clinical ResearchEndocrinology
Wei Luo, Ke Chen, Xingzhi Li
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis examined the relationship between serum 25-hydroxyvitamin D levels and thyroid diseases, including autoimmune thyroid diseases (AITDs). The analysis included 38 studies and found that patients with thyroid diseases had significantly lower vitamin D levels compared to controls, with a weighted mean difference of -5.42 ng/mL (95% CI, -6.61 to -4.67; P < .001), particularly in AITDs.
Key findings
- Patients with thyroid diseases had serum vitamin D levels lower by 5.42 ng/mL compared to controls.
- Graves' disease patients showed a vitamin D level reduction of 4.11 ng/mL.
- Hashimoto's thyroiditis patients had a vitamin D level decrease of 7.53 ng/mL.
- Unclassified AITD patients had a reduction of 2.23 ng/mL in vitamin D levels.
Why it matters
Understanding the association between vitamin D levels and thyroid diseases may help clinicians assess potential risk factors and guide management strategies for patients with thyroid conditions, particularly autoimmune types.