Boesenbergia rotunda extract-based mucoadhesive mouth gargle for chemoradiation-induced oral mucositis: A prospective randomized controlled study.
Support Care CancerOct 3, 2026 (epub)
Phitjira Sanguanboonyaphong, Anyamanee Lapmag, Warisada Silaon et al.
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In 30 seconds
This randomized controlled trial evaluated the efficacy of a Boesenbergia rotunda extract-based mouth gargle in managing chemoradiation-induced oral mucositis in head and neck cancer patients. The study found a significantly lower incidence of oral mucositis in the BR extract group compared to the control group (30.4% vs. 41.1%, p = 0.04).
Key findings
- The incidence of overall oral mucositis was 30.4% in the BR group compared to 41.1% in the control group (p = 0.04).
- Lip swelling at week 3 occurred in 1.8% of the BR group versus 14.3% in the control group (p = 0.03).
- BR extract was non-cytotoxic at concentrations below 1 µg/mL.
Why it matters
Oral mucositis is a common and painful complication of cancer treatment, impacting patient quality of life. Effective management strategies are essential for improving patient outcomes during chemoradiotherapy.