Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Cognitive Outcome after Stroke: A Systematic Review.
Prach Uthayo, Marc Feldman, Natalie Olivares
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In 30 seconds
This systematic review examined the association between the BDNF Val66Met polymorphism and cognitive outcomes in 2,494 adults post-stroke. The review found that Met-allele carriers generally had poorer cognitive outcomes, particularly in global cognition and memory, although results varied across studies. Four out of five studies reported significant genotype-related differences in cognitive performance.
Key findings
- Met-allele carriers had significantly lower 12-month Montreal Cognitive Assessment scores after adjustment for covariates.
- Three studies indicated poorer cognitive outcomes among Met-allele carriers, while one study reported the opposite.
- Memory was the most consistently affected cognitive domain among Met carriers.
- One study noted poorer cognitive functional recovery in Met carriers.
Why it matters
Understanding the genetic factors influencing post-stroke cognitive impairment can help clinicians identify at-risk patients and tailor rehabilitation strategies. This knowledge may guide future research into targeted interventions.
What to keep in mind
Substantial heterogeneity in study populations, genotype classifications, and cognitive measures limited the synthesis of findings.