Navigating the unexpected: management of incidental severe Factor V deficiency in term pregnancy.

BMJ Case RepOct 5, 2026 (epub)
Case ReportObstetrics & GynecologyHematology

Sri Vaishnavi Satakshi Challa, Amirtha Kuberan, Usha Rani Godla

✦ AI-curated · Sources linked

Case in brief

A primigravida was found to have severe Factor V deficiency (<1% activity) during routine preoperative evaluation for an elective caesarean section, despite being asymptomatic and having no bleeding history. Prothrombin time and activated partial thromboplastin time were significantly prolonged. Management included multidisciplinary planning, fresh frozen plasma transfusion, and general anaesthesia for the caesarean section, resulting in a healthy delivery without complications.

Diagnostic / clinical pearl

This case illustrates the poor correlation between Factor V levels and bleeding risk, emphasizing the importance of thrombin time in assessing coagulation defects.

Source

PubMed · PMID 42833854

Published in BMJ Case Rep. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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