Hair Follicle-Derived Grafting for Chronic Cutaneous Wounds: A Systematic Review of Clinical Outcomes.
Mara Hartoyo, Mounika Vattigunta, Jose A Jaller
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In 30 seconds
This systematic review evaluated the clinical outcomes of hair follicle-derived grafting techniques for chronic cutaneous wounds, analyzing 16 studies with 239 patients. The review found that split-thickness scalp grafts achieved 100% complete healing across 54 wounds, while follicular unit grafts had an overall closure rate of 84% across 80 wounds, indicating promising results for chronic wound management.
Key findings
- Split-thickness scalp grafts achieved 100% complete healing across 54 wounds.
- Follicular unit grafts demonstrated an overall closure rate of 84% across 80 wounds.
- Closure rates for biologic follicular preparations varied from 30% to 100% across 70 wounds.
- Adverse events were limited and mild across the studies.
Why it matters
The findings suggest that hair follicle-derived grafting techniques may offer effective treatment options for chronic nonhealing wounds, which are often challenging to manage. Understanding these outcomes can guide clinicians in selecting appropriate interventions for patients with recalcitrant wounds.
What to keep in mind
Heterogeneity in study design and outcome reporting was noted, indicating a need for standardized, high-quality trials.