5-year survival rate and determinants of decreased survival among patients with breast cancer in Africa: a systematic review and meta-analysis.
Chalie Mulugeta, Tadele Emagneneh, Getinet Kumie et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the 5-year survival rate of breast cancer patients in Africa, analyzing 55 studies with 19,577 participants. The pooled 5-year survival rate was found to be 40.38%. The study identified advanced tumor characteristics and patient-related factors, such as illiteracy, as significant determinants of decreased survival.
Key findings
- The pooled 5-year survival rate for breast cancer in Africa was 40.38% (95% CI 33.92 to 46.83%).
- Tumor stage >2 was associated with a hazard ratio (HR) of 3.06 (95% CI 2.02 to 4.09).
- Illiteracy was linked to a significantly higher risk of reduced survival with an HR of 6.54 (95% CI 4.39 to 8.69).
- Single-agent chemotherapy was associated with an HR of 1.78 (95% CI 1.04 to 2.53) for reduced survival.
Why it matters
Understanding the low survival rates and their determinants in breast cancer patients in Africa is crucial for developing targeted interventions. This knowledge can guide healthcare policies aimed at improving early detection, treatment access, and patient education, ultimately enhancing survival outcomes.