Randomised controlled trial of fluoxetine versus naltrexone in compulsive sexual behaviour disorder.
BMJ Ment HealthOct 6, 2026 (epub)
Clinical ResearchPsychiatry
Josephine Savard, Marta Piwowar, Roberth Adebahr et al.
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In 30 seconds
This randomized controlled trial compared the efficacy and tolerability of fluoxetine and naltrexone in 80 participants with compulsive sexual behaviour disorder (CSBD). No significant difference in symptom reduction was found between the two medications at the primary endpoint. However, distinct patterns of symptom improvement and adverse effects were observed.
Key findings
- No statistically significant difference in HD:CAS score reduction between fluoxetine and naltrexone at week 8.
- 5.1% of fluoxetine participants withdrew due to adverse events.
- 10.3% of fluoxetine participants discontinued treatment, compared to 15% for naltrexone.
Why it matters
Understanding the comparative effectiveness and side effect profiles of fluoxetine and naltrexone can help clinicians make informed decisions for treating CSBD, tailoring approaches to individual patient needs.