68Ga-DOTATATE PET/CT Detection of Hypertrophic Osteoarthropathy in a Pediatric Patient With Neuroblastoma Following Anti-GD2 Immunotherapy.
Siqi Li, Xiaoya Wang, Keyu Zhang et al.
✦ AI-curated · Sources linked
Case in brief
A 5-year-old boy with high-risk neuroblastoma underwent 68Ga-DOTATATE PET/CT to assess response after anti-GD2 immunotherapy. Imaging showed symmetric increased uptake in both femora and tibiae, accompanied by periostosis. 18F-MFBG PET/CT showed no abnormal uptake, and no metastases were identified. The findings were diagnosed as hypertrophic osteoarthropathy, reported as a rare complication following anti-GD2 therapy.
What made this case unusual
The symmetric long-bone uptake and periostosis on 68Ga-DOTATATE PET/CT represented hypertrophic osteoarthropathy rather than metastatic disease; 18F-MFBG PET/CT showed no abnormal uptake.
Diagnostic / clinical pearl
In a child with neuroblastoma after anti-GD2 immunotherapy, symmetric long-bone uptake with periostosis on 68Ga-DOTATATE PET/CT may indicate hypertrophic osteoarthropathy, particularly when metastatic disease is not found.