Effect of injectable platelet rich fibrin augmented with vitamin c compared to injectable platelet rich fibrin alone on healing of necrotic mature single rooted teeth with chronic periapical periodontitis following regenerative endodontic therapy (a randomized controlled trial).
Wesam Osama Hassan, Ahmed S ElSheshtawy, Manal Mohamed Abdelbaki et al.
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In 30 seconds
This randomized controlled trial compared injectable platelet-rich fibrin (i-PRF) with and without vitamin C during regenerative endodontic treatment in 28 healthy patients with necrotic mature single-rooted teeth and chronic apical periodontitis. Fourteen patients received each approach, with healing assessed by CBCT and periapical radiographs over 12 months, alongside pain and clinical status. Both groups had significant lesion reduction at 12 months (P = 0.001), but there was no significant between-group difference in postoperative lesion size (P = 0.981) or reduction magnitude (P = 0.497). Pain was comparable, and all teeth remained asymptomatic.
Key findings
- Both groups showed significant periapical lesion reduction at 12 months (P = 0.001).
- Postoperative lesion size and reduction magnitude did not differ significantly between groups (P = 0.981 and P = 0.497, respectively).
- Pain scores were comparable between groups at all time points (P > 0.05); all teeth remained asymptomatic during follow-up.
Why it matters
The findings suggest that adding vitamin C to i-PRF did not produce a detectable advantage in radiographic healing or postoperative pain in this study. The comparable outcomes provide a useful clinical comparison of two scaffold approaches in regenerative endodontic treatment, while the observed improvement in both groups supports further evaluation of these approaches.
What to keep in mind
The trial included 28 patients and followed outcomes for 12 months, limiting the precision and duration of the evidence.