Post-Stroke Depression and Determinants in Ethiopia; A Systematic Review and Meta-Analysis.
Getanew Kegne Nigatie, Berhanu Wale Yirdaw, Getaw Wubie Assefa et al.
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In 30 seconds
This systematic review and meta-analysis examined the prevalence and determinants of post-stroke depression (PSD) in Ethiopia, combining findings from eight studies. The pooled prevalence was 40.9% (95% CI: 26.52-55.28, p < 0.001), with substantial heterogeneity across studies (I 2 = 91.1%, p < 0.001). Female sex (OR 3.51, 95% CI: 1.87-6.58), illiteracy (OR 2.02, 95% CI: 1.29-3.17), and age over 40 years (OR = 1.59, 95% CI: 1.09, 2.32) were associated with PSD.
Key findings
- Pooled PSD prevalence in Ethiopia was 40.9% (95% CI: 26.52-55.28, p < 0.001).
- Female sex was associated with PSD (OR 3.51, 95% CI: 1.87-6.58).
- Illiteracy (OR 2.02, 95% CI: 1.29-3.17) and age over 40 years (OR = 1.59, 95% CI: 1.09, 2.32) were also associated with PSD.
- The included studies showed substantial heterogeneity (I 2 = 91.1%, p < 0.001).
Why it matters
The pooled estimate indicates that PSD is common among the Ethiopian populations represented in the included studies. The reported associations may help identify groups warranting attention during post-stroke assessment, while the substantial variation between studies cautions against assuming the pooled prevalence applies uniformly across settings.
What to keep in mind
The meta-analysis included only eight studies and had substantial heterogeneity (I 2 = 91.1%), limiting confidence that the pooled prevalence represents all Ethiopian settings.