The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review.
João Henrique Ferreira França, Renale Beserra de Melo Freitas, Geovanne Lucas Rodrigues Rosendo et al.
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In 30 seconds
This qualitative systematic review assessed cannabidiol (CBD) for cutaneous wound healing, including in vivo studies and clinical trials identified through searches of seven databases. Six studies were included. Four of the five studies reporting relevant outcomes found benefits, including greater wound closure, collagen deposition and angiogenesis, alongside reduced inflammation and oxidative stress; one study found no significant difference from control. Findings were heterogeneous, and the authors concluded that evidence remains limited and that more robust clinical studies are needed.
Key findings
- Four of five studies reported beneficial effects of CBD on wound-healing outcomes.
- Reported benefits included increased wound closure, collagen deposition and angiogenesis, and reduced inflammation and oxidative stress.
- One study found no significant differences compared with the control group.
Why it matters
Wound healing involves tissue repair and inflammation, and the review identifies several potentially relevant effects of CBD across the included studies. However, the small evidence base and heterogeneous results mean these findings do not establish clinical efficacy. The review highlights the need for stronger clinical evidence before CBD’s role in cutaneous wound care can be determined.
What to keep in mind
Only six studies were included, results were heterogeneous, and one study found no significant difference from control. The review reports that more robust clinical studies are needed.