A 35-Year-Old Woman With Multiple Sclerosis and a New Atypical Thalamic Lesion: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.
Neurol Neuroimmunol NeuroinflammOct 14, 2026 (epub)
Nara Miriam Michaelson, Isabel C Arrillaga-Romany, Justin T Jordan et al.
✦ AI-curated · Sources linked
Case in brief
A 35-year-old woman with multiple sclerosis developed an enlarging thalamic lesion. Although new or enlarging lesions in MS can indicate disease activity, the lesion was ultimately diagnosed as a diffuse midline glioma rather than attributed to MS.
What made this case unusual
An enlarging thalamic lesion in a patient with MS represented a tumor mimic rather than MS disease activity.
Diagnostic / clinical pearl
Do not assume an enlarging brain lesion in a patient with MS is a relapse; atypical MRI findings warrant prompt evaluation for alternative diagnoses, including tumor.