Effect of Oliceridine on Early Postoperative Recovery in Children Undergoing Adenotonsillectomy: A Prospective, Double-Blind, Randomized Controlled Trial.
Yuan Wang, Zhichun Cui, Zhonggang Cheng et al.
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From the abstract
Children undergoing adenotonsillectomy may be vulnerable to opioid-related adverse effects, creating a need for analgesic strategies that support rapid postoperative recovery. This study compared the perioperative effects of oliceridine and sufentanil in children undergoing adenotonsillectomy under general anesthesia.
Reported results
Extubation time was shorter with oliceridine than with sufentanil (35.4 ± 8.5 vs 42.6 ± 14.9 min; mean difference, -7.16 min; 95% CI, -12.59 to -1.74; p = 0.010). PACU stay duration was also shorter with oliceridine (median, 55 [47.5, 65] vs 65 [53.8, 70] min; estimated location shift, -10.00 min; 95% CI, -15.00 to <0.00; p = 0.011).
Authors' conclusions
Compared with sufentanil, oliceridine was associated with shorter extubation time and PACU stay duration in children aged 3-10 years undergoing adenotonsillectomy under general anesthesia. These findings suggest that oliceridine may facilitate early postoperative recovery, although larger studies are needed to further characterize its comparative safety.