Recurrent Primary Angiosarcoma of the Breast: Challenges and Pitfalls in a Case Report.
Chiara Valeria Pirrottina, Angela Bucaro, Alejandro Martin Sanchez et al.
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Case in brief
A patient presented with a breast lesion and skin involvement; histopathology and immunohistochemistry confirmed low- to intermediate-grade primary breast angiosarcoma. After skin-reducing mastectomy, the disease recurred early and progressed systemically despite radiotherapy and multiple lines of chemotherapy. The patient’s overall survival was 102 months from diagnosis, despite progressive disease.
What made this case unusual
Survival of 102 months was unusually prolonged for this aggressive, recurrent disease; the report does not establish which, if any, treatments contributed to that outcome.
Diagnostic / clinical pearl
Histopathological and immunohistochemical assessment is central to confirming primary breast angiosarcoma, and recurrence risk supports prolonged surveillance.