99m Tc-FAPI-46 SPECT/CT in Ewing Sarcoma : Findings in Diverse Metastatic Presentations.

Clin Nucl MedOct 20, 2026 (epub)
Case ReportOncology (Medical)Nuclear MedicineRadiology (Diagnostic)

Faeze Rabani, Mohammad Hadi Samadi, Sajjad Sadeghpour et al.

✦ AI-curated · Sources linked

Case in brief

Two young men with advanced metastatic Ewing sarcoma underwent 99mTc-FAPI-46 SPECT/CT. In one, imaging showed uptake in multiple osteoblastic skeletal metastases and pleural lesions. In the other, uptake was seen in a recurrent spinal tumor, an invasive neck mass, and extensive lytic bone lesions, with discordant uptake in the thorax. The report describes high tumor-to-background contrast and visualization of both skeletal and soft-tissue disease across these presentations.

What made this case unusual

The cases showed FAPI uptake across contrasting metastatic patterns, including osteoblastic and lytic bone lesions, pleural disease, and a recurrent spinal tumor, alongside discordant thoracic uptake in one patient.

Diagnostic / clinical pearl

In these cases, 99mTc-FAPI-46 SPECT/CT visualized diverse skeletal and soft-tissue Ewing sarcoma metastases with high tumor-to-background contrast; thoracic uptake could be discordant.

Source

PubMed · PMID 42912546

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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