SPECT/CT With 99m Tc-MIBI as an Early Indicator of the Success of Radiofrequency Ablation of Parathyroid Adenomas.

Clin Nucl MedOct 20, 2026 (epub)
Case ReportNuclear MedicineEndocrinology

Ignacio Jiménez Hernando, Aurelio López Guerra, María Miguélez González et al.

✦ AI-curated · Sources linked

Case in brief

A 55-year-old man with hypercalcemic primary hyperparathyroidism had a right inferior parathyroid adenoma localized by 99m Tc-MIBI SPECT/CT. After he declined surgery, the adenoma was treated with radiofrequency ablation. Calcium levels progressively normalized, but PTH remained mildly elevated at 6 months. Follow-up SPECT/CT showed no residual adenomatous uptake; PTH subsequently normalized at 1 year, consistent with delayed biochemical cure.

What made this case unusual

Despite persistent mild PTH elevation at 6 months, follow-up SPECT/CT showed no residual adenomatous uptake and preceded subsequent PTH normalization.

Diagnostic / clinical pearl

After radiofrequency ablation, absent adenomatous uptake on 99m Tc-MIBI SPECT/CT may indicate treatment success even when PTH remains mildly elevated.

Source

PubMed · PMID 42912547

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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