Disease trajectory in cerebral amyloid angiopathy: a matter of time.
Marialuisa Zedde, Vincenzo D'Agostino, Francesca Romana Pezzella et al.
✦ AI-curated · Sources linked
Case in brief
A 75-year-old woman diagnosed with possible cerebral amyloid angiopathy (CAA) in 2016 had a spontaneous right prerolandic convexal subarachnoid hemorrhage and MRI evidence of small-vessel disease. Over the reported 11-year follow-up, imaging showed increasing leptomeningeal involvement and cortical superficial siderosis, and she later developed a lobar intracerebral hemorrhage in 2026. The case documents evolving clinical and neuroradiological manifestations of possible CAA.
What made this case unusual
The reported trajectory included progression from convexal subarachnoid hemorrhage and small-vessel disease findings to leptomeningeal involvement, cortical superficial siderosis, and lobar intracerebral hemorrhage.
Diagnostic / clinical pearl
In possible CAA, serial imaging may reveal evolving hemorrhagic and leptomeningeal features; interpret findings in the context of the patient’s changing clinical and radiological course.
Why it matters
The case illustrates that CAA can follow varied trajectories, supporting individualized assessment of its natural history.