Comparative efficacy of common adjuvant treatments after resection of colorectal liver metastases: A systematic review and network meta-analysis.
Yuzheng Zhou, Qianru Wang, Likun Liu et al.
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In 30 seconds
This systematic review and network meta-analysis compared adjuvant strategies after resection of colorectal liver metastases, including systemic chemotherapy, hepatic arterial infusion chemotherapy (HAIC), and perioperative chemotherapy. Eighteen studies were included. Adjuvant chemotherapy and perioperative chemotherapy improved disease-free survival (DFS) compared with surgery and adjuvant HAIC, while no statistically significant overall-survival (OS) differences were found among strategies. HAIC combined with intravenous chemotherapy had the highest probability of ranking best for DFS (85.01%) and OS (52.46%), although the authors concluded that further validation is needed.
Key findings
- Adjuvant chemotherapy and perioperative chemotherapy significantly improved DFS compared with surgery and adjuvant HAIC.
- No statistically significant OS differences were found among the therapeutic strategies.
- HAIC combined with intravenous chemotherapy had the highest probability of ranking best for DFS (85.01%) and OS (52.46%).
Why it matters
The analysis compares several approaches used after resection of colorectal liver metastases, where the optimal strategy for survival outcomes remains uncertain. Its findings suggest that DFS and OS rankings may not align, and that probability rankings should not be mistaken for demonstrated superiority when the analysis found no statistically significant OS differences.
What to keep in mind
The authors state that the results require further validation; the findings are based on a network meta-analysis of 18 studies.